Diploma in Genomics

Bharathiar University
In Coimbatore

Price on request
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Important information

  • Diploma
  • Coimbatore

To make the students to familiar with genome map, comparative genomics, structural and. functional genomics.

Important information

Where and when

Starts Location
On request
Bharathiar University, Coimbatore, 641046., Tamil Nadu, India
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Course programme

Subject title : GENOMICS
Course number : 07BIC07 Number of lecture hours: 5
Subject description :
This paper deals with genome map, comparative genomics, structural genomics, functional
genomics and regulation.
To make the students to familiar with genome map, comparative genomics, structural and
functional genomics.
Understand the genome architecture and extracting information like gene function, gene
regulation, protein evolution and targets for drug designing
Definition of Genome, Genome sequencing, Genome map: Types of Genome maps and
their uses, High and low-resolution map, Map elements, Polymorphic markers, Types of
maps: Cytogenetic, Linkage map, Transcript map, Physical map, Comparative map,
Integrated map, STS content maps, Map repositories: NCBI - Entrez Human genome map
viewer, OMIM - Online Mendelian Inheritance in Man, Linkage map resources: CEPH
reference pedigree, CHLC - Cooperative human linkage center, Radiation hybrid map
resources. Practical uses of genome maps: Locating genomic regions, Target identification,
Arrangement of genes, SNP diagnosis, Positional specific cloning,
Genome Anatomies The anatomy of the Eukaryotic Genome -The special features of
metaphase chromosomes, where are the genes in the genome? Families of genes,
pseudogenes - Eukaryotic organelle genomes, Repetitive DNA content of the human
Transcriptomes and Proteomes
Genome Expression in outline; The RNA content of the Cell- the Transcriptome - yeast
and human; The Protein content of the cell - the link between the Transcriptome and the
Annotation of the Genome: Structural annotation (Locating coding regions
and other structural elements of the gene). Various approaches in gene prediction:
ORF prediction, Gene prediction in prokaryotes and eukaryotes, Hidden Markov Model,
Pattern discrimination, Evaluation of gene prediction methods, Prediction of promoter
sequences, Functional annotation: (Prediction of gene function), Employing the similarity
in the sequence, gene family and metabolic pathway. Employing the conserved domain,
Profile and motif comparison, EST Comparison. Analysis of Human Genome.
Comparative Genomics:
Purpose and Methods of comparison, Tools for genomic comparison: Applications of
Comparative Genomics, Reconstruction of metabolic pathway, Predicting regulatory
elements, Identifying targets, examination of domain function, analysis of conserved
Genome projects and Model Organism research -Yeast; Drosophila; C. elegans; and Mouse
- a comparative analysis. Comparative genomics as an aid to gene mapping and in the
study of human diseases.
Functional Genomics:
Gene expression analysis by cDNA micro arrays, SAGE, Strategies for generating ESTs
and full length inserts; EST clustering and assembly; EST databases (DBEST, UNIGENE);
Expression and regulation of entire set of genes, Sporulation Vs Vegetative condition in
yeast and Bacillus.

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