M.Pharm:Pharmaceutical Technology (Formulations)

National Institute of Pharmaceutical Education and Research
In Ludhiana

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Important information

  • Master
  • Ludhiana
Description

Important information
Venues

Where and when

Starts Location
On request
Ludhiana
National Institute of Pharmaceutical Education and Research (NIPER) Sector 67, S.A.S., 160062, Punjab, India
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Frequent Asked Questions

· Requirements

B.Pharm.

Course programme

* Preformulation studies of new molecular entities
* Prototype formulation development and product/process challenge studies on solid and liquid dosage forms
* Solid state characterization of pharmaceuticals
* Generation of polymorphs, pseudo-polymorphs and amorphous form; Characterization using thermal, spectroscopic, crystallographic (powder and single crystal) techniques; Solubility advantage; Thermodynamic characterization - van't Hoff plots; Effect of polymorphism on product performance; solid state transformations during pharmaceutical processing; regulatory implications
* Generation of co - crystals to improve aqueous solubility of poorly water soluble drugs
* High energy amorphous form - Generation; characterization using thermal, spectroscopic, crystallographic techniques; Thermodynamic parameters like enthalpy, entropy, specific heat; Kinetic characterization of the molecular mobility of amorphous systems using enthalpy relaxation studies, cocnept of fragility and fictive temperature; Stabilization of the amorphous systems using anti - plasticizer, specific molecular interactions, crystal growth inhibitors; Solubility advantage of amorphous syetms; Molecular interactions vis a vis stable crystalline form; Devitrification during storage and dissolution stage; Ternary amorphous dispersions to improve aqueous solubility
* Improved powder properties using particle engineering and co-processing of pharmaceuticals; Study of compression behavior; Heckel's plots; Physico - technical properties
* Reverse engineering of generic formulations to - propose quantitative formula, solid state characteristics of the API in the dosage form, information on manufacturing process; Concept of 'formulation equivalence' to develop bio-equivalent generic products
* Improvements of oral bioavailability using lipidic systems
* Intestinal permeability studies and permeation enhancement of drugs using excipeints
* Stabilization of protein drugs during lyophilization


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