M.S. (Pharm.):Pharmacology & ToxicologyNational Institute of Pharmaceutical Education and Research
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B.Pharm.; B.V.Sc.; M.B.B.S.
Department of Pharmacology and Toxicology has the facilities to carry out pharmacological screening of NCEs. The department can enter into project collaborations in regulatory toxicological testing, viz., acute, sub-chronic and chronic toxicity testing. The departmental research activities are concentrated in the following areas:
* Opioid tolerance, supersensitivity and dependence mechanisms
* Role of different subtypes of angiotensin receptors in hypertension and diabetic vascular complications
* Understanding the mechanisms of diabetic complication and development of NIDDM & insulin resistance models in rodents; screening of synthetic and natural products for their antidiabetic activity
* Role of alpha adrenoceptors in benign prostatic hyperplasia
* Understanding the molecular mechanisms involved in ischaemic stroke
* Evaluation of novel neuroprotective approaches for the treatment of cerebral ischemia
* Development of animal models of cerebral ischemia
* Understanding the mechanisms of diabetic neuropathy
* Role of adenosine receptors subtypes in diabetic neuropathic pain
* Evaluation of various neuroprotective approaches in diabetic neuropathy
* Screening of NCEs for antileismanial activity.
* Development of rat model for Alzheimer's disease and screening of NCEs on learning and memory in rats
* Production of monoclonal antibodies against Plasmodium yoelii nigeriensis antigens with the objective of characterization of protective antigens
* Molecular mechanisms of protection, cytoadherence, immune evasion and red cell invasion in malaria
* Biotherapeutics and chemotherapeutics evaluation of potential antimalarial, antitubercular, antileishmanial and antiamoebic agents in vitro and in vivo
* Study of the opioids-induced bidirectional molecular signaling within the neuroimmune network with a view to develop new immunomodulators.
* Histone modifications as targets for drug discovery
* Molecular mechanism involved in toxicant and oxidative stress induced process of cell death