M.Phil in Magnetic ResonanceUniversity of Lucknow
Price on request
The University of Lucknow offers M.Phil in Magnetic Resonance course to its students. The course structure for it is as follows:
Basics of Mathematics and Computers
Basics of Mathematics pertaining to Magnetic Resonance:
Functions, Limit and their evaluation, Matrix Algebra, Eigen values and Eigen Vectors, complex numbers, Fourier transformation. Applications of Fourier transformation
Basics of Computers:
Introduction to operating systems, windows, LINUX and UNIX
Basics of Structural Chemistry:
Stereochemistry, peptides and protein structure, Nucleic acid structures, oligosaccharide structures
Basics of Statistics:
Different sampling methods, design of experiments/study protocol. Different statistical tests like parameteric and non-parametric test.
Parametric: t-test, ANOVA, correlation, linear regression, Principal component analysis, Partial least square (PLS), Discriminent functional analysis.
Non-Parametric: Mann-Whitney U-test, wilcoxon matched pair test.
Basics of Biochemistry and Plant Sciences
Living systems at the molecular level, cell wall, cell membrane and various organelles their functions, cell bioenergetics, intermediary metabolism of carbohydrate, lipids, proteins, amino acids, hormones and disease, water homeostasis and mineral metabolism, prokaryotes and eukaryotes bacteria and human relation.
Basics of Psychology:
Brain behavior and consciousness, cognitive neuroscience; effect process and disorders and basics of social neuroscience.
Basics of Magnetic Resonance:
Basics of Quantum Mechanics in NMR, Spin states of various nuclei, phenomenon of resonance, Vector model, laboratory frame and rotating frame, pulses, FT NMR
Basics of Human Anatomy
(I) Parameters in NMR of important spin ½ nuclei (1H, 13C, 19F, 15N, 31P etc.):
a. Chemical Shift
b. Spin-Spin Coupling
e. NOE and Exchange Spectroscopy
f. Diffusion and Principles
g. Contact shift and pseudo contact shifts
(ii) Knight shifts
Paper 2 Principles and methodology
Solid State NMR
MAS, CP, Multi-pulses homonuclear decoupling, heteronuclear decoupling experiments
ESR and NQR
Basic principles of spin 1 and 3/2 and applications
Spectral analysis including spectral editing and practice in one-dimension with examples:
Weakly and strongly coupled spectra and their analysis
Concept of phase cycling. Product operator formalism. Editing techniques like SEFT, INEPT, DEPT, concept of inverse experiments, reverse INEPT, DEPT and concept of Gradient in NMR experiments.
Spectrometer components and their function, super conducting magnets, Probe head and their functions
Basic principles of two-dimensional NMR
Various two-dimensional NMR techniques in liquids and solids:
SECSY, COSY, Relay COSY, COSYLR, TOCSY, HMQC, HSQC, HMBC, gs-HMQC, gs HMBC, gsH2BC, gs-HSQC using adiabatic pulses, NOESY, ROESY, HSQC-TOCSY, HSQC-NOESY, SLF, CSC, REDOR, PISEMA, SAMMY etc.
Zero filling, window functions, MEM, TPPI, States, States TPPI, linear prediction.
Higher dimensional NMR:
3D COSY, 3D HNCA, HNCO, HNCACO etc. and still higher dimension NMR
Localized MRS Principles
Fourier imaging, k-space, Density weighted, T1 weighted, T2 weighted, Magnetization transfer, Diffusion weighted, MRA, perfusion imaging, DTI and their applications. CSI. Artifact in MRI and their solutions. fMRI Principles
EPI, BOLD, FLASH, data processing etc.
Liquid Crystal NMR:
Types of liquid crystals, liquid crystals as solvent, Applications to chemical and Biological Systems
New developments in Magnetic Resonance
Solving various problems such as determination of molecular structure using actual examples:
Such as steroids, terpenoids, peptides, oligosaccharides, alkaloids etc.
Specialized lectures in related interdisciplinary applications
Metabonomics and Metabolomics biological in clinical and plant systems by NMR and their applications:
Bio-fluids, tissues, cells, extract biochemical composition. Definitions of Metabonomics, Metabolomics and associated terms like xenobiotics etc. Data analysis using statistical methods.
cations in Polymers, Clinical and Industrial Science
Running and interpretation of various 1D, 1H and 13C NMR experiments. The experiments include Decoupling, DEPT, INEPT, NoE difference, T1 and T2 studies etc.
Running of various 2D experiments followed by interpretation of the results. The experiments include COSY, DQFCOSY, NOESY, TOCSY, HSQC, HMBC etc.
Running of various MRI experiments followed by interpretation of the results. These experiments include T1 and T2 weighted imaging, Spin Echo, Gradient echo etc.