Course programme
COURSE CONTENT Normal and abnormal chromosomes, Molecular genetics, developmental genetics, immunogenetics, population genetics and genetic counselling. 1. Human Chromosomes - Structure, number and classification, methods of chromosome preparation, banding patterns. Chromosome abnormalities, Autosomal abnormalities – syndromes, Sex chromosomal abnormalities – syndromes, Molecular and Cytogenetics. 2. Single gene pattern inheritance, Autosomal and Sex chromosomal patterns of inheritance, Intermediate pattern and multiple alleles, Mutations, Non Mendelian inheritance, Mitochondrial inheritance, Genomic imprinting, parental disomy. 3. Multifactorial pattern of inheritance: Criteria for multifactorial inheritance, Teratology, Structure of gene, Molecular Screening, Cancer Genetics – Haematological malignancies, Cancer Genetics, Pharmacogenetics. 4. Reproduction Genetics- Male infertility, Female Infertility, assisted reproduction, Preimplanation genetics, Prenatal diagnosis, Genetic Counselling Ethics and Genetics. PRACTICAL DNA Isolation from peripheral blood lymphocytes, Polymerase Chain Reaction (PCR), Fluorescence In-Situ Hybridization (FISH), Chromosomal Analysis DEVELOPMENTAL ANATOMY COURSE CONTENT Gametogenesis, early human development, general and systemic embryology,environmental and genetic influences on normal growth and development, teratogenesis. PRACTICAL Models, specimens of early human development and slides of chick and pig embryos to correlate avian and mammalian early development with human development. Specimens of congenital malformations. 4 Syllabus M Sc / M Biotech — AIIMS IMMUNOLOGY COURSE CONTENT Immune system and the cell types involved in defense mechanisms of the body. Gross features, cytoarchitecture, functions, development and histogenesis of various primary and secondary lymphoid organs in the body. Biological and clinical significance of the major histocompatibility complex of man including its role in transplantation, disease susceptibility/resistance and genetic control of the immune response. Common techniques employed in cellular immunology and histocompatibility testing. Molecular hybridization and PCR technology in immunology research particularly mechanism of antigen presentation, structural and functional relevance of the T cell receptor, genetic control of the immune response, molecular basis of susceptibility to disease. PRACTICAL Techniques of DNA preparation, electrophoresis and southern blot hybridization. SECTION – 3 NEUROANATOMY COURSE CONTENT Brain and its environment, Development of the nervous system, Neuron and Neuroglia, Somatic sensory system, Olfactory and optic pathways, Cochleovestibular and gustatory pathways, Motor pathways, Central autonomic pathways, Hypothalamo-hypophyseal system, Cross sectional anatomy of brain and spinal cord. PRACTICAL Identification of structures in sections of brain stem and spinal cord at different levels. Staining nervous tissue using Nissl’s staining and other special stains. RECOMMENDED BOOKS 1. Gray’s Anatomy 38th edition, 1995 reprint in 2000 Williams et al Churchill Livingstone 2. Wheaters Functional Histology 4th ed.(2000) B. Young and J.Heath Churchill Livingstone www.med.uc.edu.embryology 3. Histology: A text & atlas 3rd edition (1995) M.H.Ross, E.& L.J. Williams & Wilkins 4. Medical Embryology 8th edition Jan Langman William and Wilkins 5. Genetics in medicine 6th edition, 2001 J.S.Thompson & W.B. Saunders & Co.Philadelphia, London M.W. Thompson 6. Human Neuroanatomy 9th edition, 1996 Stuin J and Carpenter MB 7. Clinical Neuroanatomy for Medical Students Richard S. Snell Willian and Wilkins BIOCHEMISTRY — M Sc Goal The program is designed to enable a student acquire sound knowledge in the subject and develop practical skills to contribute effectively in academics and health sciences research. OBJECTIVES 1. At the end of the 2 years training in Biochemistry, the PG student is expected to demonstrate sound knowledge of general concepts and principles of Biochemistry. Evolutionary perspectives of biomolecules, cell organelles and diversity provided at the molecular level, discuss various aspects of nutrition and metabolism under different physiological conditions, explain the occurrence, regulation and interrelationship of metabolic events, identify the molecular/metabolic basis of a disease, explain concepts of body defense/immunology and detoxification, molecular and cell biology, describe the principles of various biochemical techniques and instrumentations and analyze and interpret the data. 2. Plan & conduct lecture, practical demonstrations & tutorial classes. 3. Critically review & comment on research papers 4. Prepare research protocols to conduct experimental studies, analyse, interpret diseases, experimental results of generate hypothesis. 5. Be familiar with literature survey / computer skills, basic knowledge of biostatistics. METHODOLOGY Following methods are used to facilitate learning and training of the students. A. Theory 1. Tutorials: will be held for 1 hour duration, at least twice a month. The objective is to provide an opportunity to the students to have interaction with the teachers and gain maximum coordinated information on the subject.
