M.Sc. (Genetics)

Maharshi Dayanand University
In Rohtak

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Important information

  • Master
  • Rohtak
Description

Important information
Venues

Where and when

Starts Location
On request
Rohtak
Maharshi Dayanand University,Rohtak - 124001,Haryana , 124001, Haryana, India
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Course programme

Unit-I
1.1 Organization of genome in humans : General features of
chromosomes, reiterated sequences and their detection, protein
coding genes, pseudogene;
1.2 Gene mapping : Gene mapping by somatic cell hybridization, top
down approach to molecular mapping, restriction maps and contig
construction (the bottom up approach);
1.3 Engineering chromosomes : Yeast artificial chromosome, making
YACs, MACs (mammalian artificial chromosomes) and satellite
DNA's artificial chromosomes (SAT ACS).\
Unit-II
2.1 Molecular explanation of dominance, recessiveness, incomplete
peneterance and variable expressivity.
2.2 Identifying the genetic basic of disease : Positional analysis
experimental strategy;
2.3 Identification of specific disease gene in Huntington's disease,
DMD and cystic fibrosis.
Unit-III
3.1 Genetic screening : Prenatal, neonatal and adult screening;
3.2 Prenatal diagnosis : RFLP and Prenatal counselling;
3.3 Treatment of genetic disease : Gene therapy (criteria and technical
aspects), gene delivery systems; viral vectors and micro injection;
germ line therapy
Uni-IV
4.1 Studying the whole genome : Pulse field gel electrophoresis (to
make large scale maps), cloning of huge DNA segment, automated
DNA sequencing;
4.2 Human genome project : History & concepts human genome
project, gateways to access human genome, goals, role of
sequencing, distribution of GC content, cpg island & recombination
rules, main conclussions, current activities, STS proposal;
4.3 Social and ethical issues in human genome research.


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