P.hd in BiochemistryNational Institute for Research in Reproductive Health
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P.hd in Biochemistry
National Institute for Research in Reproductive Health (NIRRH), formerly known as Institute for Research in Reproduction is a premier research institute of the Indian Council of Medical Research (ICMR). It is situated in the vicinity of a number of hospitals and research institutes in central Mumbai. Since its inception in 1970, it has been making vigorous efforts to improve the reproductive health of people through research, education and health care services. The Institute is affiliated to the University of Mumbai which awards degrees to the M.Sc. and Ph.D students in the areas of Biotechnology, Life Sciences, Biochemistry and Applied Biology. The Institute is one of the few centers in India , which can boast of a team of basic, clinical and operational research scientists and state-of-art laboratories equipped with modern facilities to carry out research on various components of reproductive health. Research programmes have also been initiated in new emerging areas such as stem cell biology, toxicology and transgenesis. The Institute is a WHO Collaborating Center for Research and Training in Reproductive Health. Collaborations are undertaken with national and international organizations in a global effort to promote research and dissemination of information on reproductive health matters .
The department is involved in research on the biochemical aspects of sperm and seminal plasma. Special emphasis is laid on the identification and characterization of sperm proteins with functional relevance that could be useful for development of male contraceptive vaccines or for diagnosis of infertility. Several sperm proteins have been identified and characterized, including hSPI, 80kDa HSA, Hoxbes2, 160kDa HIV sperm receptor. The R-17 hSPI peptide and peptides of 80kDa HSA are being evaluated for their probable development as male fertility regulating vaccinogens. We were the first to identify a CD4 independent HIV receptor on human sperm. The finding is important in elucidating the mode of entry of HIV in human sperms and vaginal epithelial cells.