P.hd in Primate BiologyNational Institute for Research in Reproductive Health
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P.hd in Primate Biology
The department is currently engaged in research programmes on elucidation of molecular basis of endometrial receptivity and implantation in primates. These studies are expected to facilitate the development of effective fertility management strategies. Our focus is to identify participants involved in these two events and investigate the functional networks amongst them. High throughput functional genomics approaches are being employed to obtain a global snapshot of these events in temporally-restricted fashion. We are focusing on identification of i) hormonally regulated cellular and secreted proteins associated with endometrial receptivity in natural menstrual cycle and ii) proteins modulated by embryonic factors during early pregnancy. Our studies have revealed novel targets of progesterone action, hitherto unknown for their endometrial presence and hormonal modulation. Currently we are exploring the mechanisms by which these target proteins contribute to endometrial receptivity. With respect to implantation in primates, we have demonstrated that even in absence of close physical interactions with the embryo, the endometrium undergoes remarkable structural and molecular transformations. A recent initiative by the department is in the area of prostate cancer pathogenesis wherein the hormonal regulation of telomerase is being investigated. These studies will unravel some of the cascades involved in growth and sustenance of prostate tumor in absence of hormones. This may also aid in development of treatment strategies for hormone-independent cancers.