The Gauhati Medical College (GMC) took its start under the stewardship of Professor I. Jahan from October, 1960 to June, 1961. Professor S.N. Sarma was transferred from AMC, Dibrugarh and he took over the charge of the Office of the Principal, Gauhati Medical College on 3rd June, 1961. Professor S.N. Sarma was the founder Principal of the Gauhati Medical College and he took great interest in the construction of the permanent college and hospital complexes. Paraclinical and clinical departments were started in the Civil Hospital Campus at Panbazar, Ulubari Maternity Home, Emigration Hospital (later on Infectious Diseases Hospital) and T.B. Hospital at Birubari, Guwahati as and when they became available.
The Govt. of Assam decided to construct the permanent buildings of the Gauhati Medical College & Hospital on the Narakachal hill. The P.W.D.,Govt. of Assam, took up the survey and started road constructions in 1962 in the Narakachal hill. The Assam Govt. Construction Corporation (AGCC) started building construction in Feb., 1962. The architects entrusted were Mr. J.K.Choudhury and Gulzar Sing of Delhi. Mr.J.K.Choudhury, an Assamese from Goalpara, was a reputed architect and also the then President of the All India Architects' Association. Hostels were given the first priority and started in the foot hills of the Narakachal hill. The hostels were completed and taken over and occupied in between August, 1965 and October, 1966. Girls' hostel could be occupied in June, 1968.
Late Mr. B.P. Chaliha, then Chief Minister of Assam, laid the foundation stone of the college building in the year 1963. The construction of the main college and administrative building at the Narakachal hill top could be started by the AGCC in April, 1965 after the road was completed to the top by the PWD. Part by part the main college building was taken over from April, 1968 to which Preclinical. Paraclinical and Central Library was shifted by August, 1968. Meanwhile, the Silchar Medical College was inaugurated in its permanent building under construction at Ghungoor on 15th August, 1968 and thereby the twin got separated. Dr. Rudra Goswami was put in charge of the Silchar Medical College.